MHC Class I Antigens In Malignant Cells: Immune Escape And Response To Immunotherapy Natalia Aptsiauri

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Published: February 26th 2013

Kindle Edition

55 pages


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MHC Class I Antigens In Malignant Cells: Immune Escape And Response To Immunotherapy  by  Natalia Aptsiauri

MHC Class I Antigens In Malignant Cells: Immune Escape And Response To Immunotherapy by Natalia Aptsiauri
February 26th 2013 | Kindle Edition | PDF, EPUB, FB2, DjVu, audiobook, mp3, ZIP | 55 pages | ISBN: | 3.59 Mb

Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrencethat ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsibleMoreAbnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeutic approaches. A complete characterization of these molecular defects is important for improvement of the strategies for the selection and follow-up of patients undergoing T-cell based cancer immunotherapy.

 Precise identification of the mechanism leading to MHC class I defects  will help to develop new personalized patient-tailored treatment protocols. There is significant new research on the prevalence of various patterns of MHC class I defects and the underlying molecular mechanisms in different types of cancer.

In contrast, few data is available on the changes in MHC class I expression during the course of cancer immunotherapy, but the authors have recently made discoveries that show the progression or regression of a tumor lesion in cancer patients undergoing immunotherapy depends on the molecular mechanism responsible for the MHC class I alteration and not on the type of immunotherapy used.

According to this notion, the nature of the preexisting MHC class I lesion in the cancer cell has a crucial impact on determining the final outcome of cancer immunotherapy. This SpringerBrief will present how MHC class 1 is expressed, explain its role in tumor progression, and its role in resistance to immunotherapy. ?



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