Adam Family of Proteases, The. Proteases in Biology and Disease, Volume 4. N.M. Hooper

ISBN: 9781280618673

Published: January 1st 2005

ebook

351 pages


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Adam Family of Proteases, The. Proteases in Biology and Disease, Volume 4.  by  N.M. Hooper

Adam Family of Proteases, The. Proteases in Biology and Disease, Volume 4. by N.M. Hooper
January 1st 2005 | ebook | PDF, EPUB, FB2, DjVu, talking book, mp3, RTF | 351 pages | ISBN: 9781280618673 | 3.64 Mb

The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for someMoreThe ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent.

These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimers amyloid precursor protein.

Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.



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